Rodrigues Jadson's extra-time winner sank Werder Bremen and ensured Shakhtar Donetsk won the last Uefa Cup final.
Luiz Adriano's delicate finish put Shakhtar in front after 25 minutes.
Werder equalised before the interval when Shakhtar keeper Andriy Pyatov could only divert Ronaldo Naldo's long-range free-kick into the net.
And it was another goalkeeping error that gave Shakhtar victory in extra-time, when Tim Wiese allowed Jadson's 97th-minute strike to squirm in.
Shakhtar deserved the victory in Istanbul, but Werder will reflect on the absence of inspirational forward Diego because of suspension.
Shakhtar Donetsk coach Mircea Lucesu:
"We have bigger aims. We now want to do things in the Champions League: Reach the quarterfinals, maybe the semi-finals.
"It was important not to allow Werder to play to their style, we contolled the game and we created most of the chances."
Werder Bremen coach Thomas Schaaf:
"We were just not fast enough and not just effective enough.
"We weren't able to play our usual football, we didn't put enough pressure on our opponents.
"We gave them too much space and lost too many balls. I congratulate Shakhtar, they were the best team on the night."
Shakhtar Donetsk: Pyatov, Srna, Kucher, Chigrinsky, Rat, Lewandowski, Fernandinho, Ilsinho (Gai 99), Jadson (Duljaj 112), Willian , Luiz Adriano (Gladkyy 89).
Subs Not Used: Khudzamov, Ischenko, Chyzhov, Moreno.
Booked: Srna, Lewandowski, Ilsinho.
Goals: Luiz Adriano 25, Jadson 97.
Werder Bremen: Wiese, Fritz (Pasanen 94), Prodl, Naldo, Boenisch, Niemeyer (Tziolis 103), Frings, Baumann, Ozil, Pizarro, Rosenberg (Hunt 78).
Subs Not Used: Vander, Tosic, Vranjes, Harnik.
Booked: Frings, Fritz, Tziolis, Boenisch.
Goals: Naldo 35.
Att: 53,100.
Ref: Luis Medina Cantalejo (Spain).
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